HGH Fragment 176-191 is a synthetic peptide fragment of human growth hormone (hGH) used in scientific research, primarily for studying fat metabolism (lipolysis and anti-lipogenesis). It is not approved for human therapeutic use outside of a formal medical research setting and is often sold as “for research use only”.
Overview
Description: The fragment consists of amino acids 176 to 191 from the C-terminal end of the full hGH molecule.
Function in Research: This specific sequence is believed to be responsible for hGH’s fat-reducing actions without causing some of the broader systemic effects of full hGH, such as increased insulin resistance or general tissue growth.
Legal Status: It is not approved by regulatory bodies like the FDA for non-medical human use and is considered an unapproved substance by the World Anti-Doping Agency (WADA). Its use for performance enhancement or as an anti-aging treatment is illegal in the U.S. and often in other countries like the UK, where it is available strictly for research purposes.
Research and Potential Uses
Scientific studies, often using animal models or in vitro cell cultures, have explored its effects:
Fat Loss: Research indicates it stimulates the breakdown of fat (lipolysis) and inhibits the formation of new fat (lipogenesis) in adipose tissue.
Cancer Treatment: Recent studies have investigated its potential to enhance the efficacy of chemotherapy drugs (like doxorubicin) against breast cancer cells when delivered via nanoparticles, by potentially helping the drugs target cancer cells more effectively.
Other Areas: It is also under investigation for potential applications in osteoarthritis treatment, cholesterol reduction, and bone/cartilage repair.
Important Considerations
Not a Supplement: Products marketed as “HGH Fragment 176-191 supplements” in pill or spray form do not legally contain the actual hGH drug; their efficacy and safety are unproven.
Safety: Its long-term safety profile in humans has not been adequately established through proper clinical trials. Potential side effects and interactions with other medications are largely unknown when used illicitly.
Medical Supervision Required: Legitimate hGH treatments are only available by prescription for specific, recognized medical conditions (e.g., diagnosed growth hormone deficiency) and are administered via injection under medical supervision.
HGH Fragment 5mg
Product Price
£21.45
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